Abstract
A series of novel and potent 6-heteroaryl-pyrrolidino-tetrahydroisoquinolines with dual histamine H(3) antagonist/serotonin transporter inhibitor activity is described. In vitro and in vivo data are discussed.
MeSH terms
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Animals
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Blood-Brain Barrier
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Histamine H1 Antagonists / chemistry
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Histamine H1 Antagonists / pharmacology*
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Mice
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Pyrrolidines / chemistry
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Pyrrolidines / pharmacology*
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Receptors, Histamine H3 / drug effects*
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Serotonin Plasma Membrane Transport Proteins / drug effects*
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Structure-Activity Relationship
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Tetrahydroisoquinolines / chemistry
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Tetrahydroisoquinolines / pharmacology*
Substances
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Histamine H1 Antagonists
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Pyrrolidines
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Receptors, Histamine H3
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Serotonin Plasma Membrane Transport Proteins
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Tetrahydroisoquinolines